Ingabe i-biomarker entsha yegazi ingasiza ukubikezela ingozi ye-Alzheimer's?

Ucwaningo olusha luphakamisa ukuthi ama-astrocyte, uhlobo lweseli yobuchopho, abalulekile ekuxhumaniseni i-amyloid-β nezigaba zokuqala ze-tau pathology.Karyna Bartashevich/Stocksy

• Ama-astrocyte asebenzayo, uhlobo lweseli yobuchopho, angasiza ososayensi baqonde ukuthi kungani abanye abantu abanolwazi olunempilo kanye namadiphozithi e-amyloid-β ebuchosheni babo bangazitholi ezinye izimpawu ze-Alzheimer's, njengamaphrotheni e-tau aphithane.
• Ucwaningo olunababambiqhaza abangaphezu kwe-1,000 lubheke ama-biomarker futhi lwathola ukuthi i-amyloid-β yayixhunywe kuphela emazingeni akhulayo e-tau kubantu ababenezimpawu zokuphinda kusebenze kabusha kwe-astrocyte.
• Okutholakele kusikisela ukuthi ama-astrocyte abalulekile ekuxhumaniseni i-amyloid-β nezigaba zokuqala ze-tau pathology, ezingashintsha indlela esichaza ngayo isifo i-Alzheimer's ekuqaleni.

Ukuqoqwa kwama-amyloid plaque kanye namaprotheni e-tau ebuchosheni sekuyisikhathi eside kubhekwa njengembangela eyinhlokoIsifo i-Alzheimer's (AD).

Ukuthuthukiswa kwezidakamizwa kuthambekele ekugxileni ekuqondiseni i-amyloid ne-tau, indiva indima engaba khona yezinye izinqubo zobuchopho, njengesistimu ye-neuroimmune.

Manje, ucwaningo olusha oluvela eNyuvesi yasePittsburgh School of Medicine luphakamisa ukuthi ama-astrocyte, angamangqamuzana obuchopho amise okwenkanyezi, adlala indima ebalulekile ekunqumeni ukuqhubeka kwe-Alzheimer's.

I-AstrocytesUmthombo Othembekilezigcwele izicubu zobuchopho.Eceleni kwamanye amangqamuzana e-glial, amaseli omzimba ahlala ebuchosheni, ama-astrocyte asekela ama-neurons ngokuwanikeza imisoco, umoya-mpilo, nesivikelo kumagciwane.

Ngaphambilini indima yama-astrocyte ekuxhumaneni kwe-neuronal yayinganakiwe njengoba amaseli e-glial awawuhambisi ugesi njengama-neurons.Kepha ucwaningo lweNyuvesi yasePittsburg luphonsela inselelo lo mbono futhi lusikhanyisela ngeqhaza elibalulekile lama-astrocyte empilweni yobuchopho nezifo.

Okutholakele kusanda kushicilelwa kuNature MedicineTrusted Source.

Ucwaningo lwangaphambilini luphakamisa ukuthi ukuphazamiseka kwezinqubo zobuchopho okungaphezu komthwalo we-amyloid, njengokwanda kokuvuvukala kobuchopho, kungase kudlale indima ebalulekile ekuqaliseni ukulandelana kwe-pathological of neuronal death eholela ekwehleni ngokushesha kwengqondo ku-Alzheimer's.

Kulolu cwaningo olusha, abacwaningi benze ukuhlolwa kwegazi kubahlanganyeli be-1,000 abavela ezifundweni ezintathu ezihlukene ezibandakanya abantu abadala abanempilo enengqondo ene-amyloid buildup nangaphandle.

Bahlaziye amasampula egazi ukuze bahlole ama-biomarker e-astrocyte reactivity, ikakhulukazi i-glial fibrillary acidic protein (GFAP), kuhlanganiswe nokuba khona kwe-pathological tau.

Abacwaningi bathole ukuthi yilabo kuphela ababenakho kokubili umthwalo we-amyloid kanye nezimpawu zegazi ezibonisa ukusebenza kwe-astrocyte okungavamile noma ukuphinda kusebenze okungenzeka babe nezimpawu ze-Alzheimer esikhathini esizayo.