Ucwaningo olusha luphakamisa ukuthi ama-arocytes, uhlobo lweseli lobuchopho, lubalulekile ukuxhuma i-amyloid-β ngezigaba zokuqala zeTau Pathology. Karyna Bartashevich / Stocksy
- Ama-Astrocys asebenzayo, uhlobo lweseli lobuchopho, angasiza ososayensi ukuba baqonde ukuthi kungani abanye abantu abanemali enempilo kanye ne-amyloid-Β
- Ucwaningo olwa nababambiqhaza abangaphezu kwenkulungwane lubuke abasebenza nge-biomaskers futhi bathola ukuthi i-amyloid-Β yaxhunyaniswa kuphela namazinga akhuphukayo eTau kubantu ababenezinkinga zokuvuselelwa kwe-astrocyte.
- Ukutholwa kusikisela ukuthi ama-astrocytes abalulekile ukuxhuma i-amyloid-β ngezigaba zokuqala zeTau Pathology, ezingashintsha indlela esichaza ngayo isifo sase-Alzheimer's.
Ukuqongelelwa kwe-Amyloid Plaques kanye namaprotheni eTangled Tau ebuchosheni sekuyisikhathi eside kubhekwe njengembangela eyinhloko yeIsifo se-Alzheimer's (isikhangiso).
Ukuthuthukiswa kwezidakamizwa kuye kwaheha ukugxila ekuqondiseni i-Amyloid naseTau, kunganaki iqhaza elingaba khona lezinye izinqubo zobuchopho, njengokuhlelwa kwe-Neuroimmune.
Manje, ucwaningo olusha oluvela e-University of Pittsburgh School of Medicine lubonisa ukuthi ama-astrocytes, anamaseli obuchopho amise izinkanyezi, adlala indima ebalulekile ekunqumeni ukuthuthuka kwe-Alzheimer's.
Umthombo we-Astrocytestrustedziningi izicubu zobuchopho. Kanye namanye amaseli akhazimulayo, amaseli okuvikela ubuchopho, ama-astrocytes asekela ama-neurons ngokubanikeza izakhamzimba, umoya-mpilo kanye nokuvikelwa kumagciwane.
Phambilini iqhaza lezinkanyezi ekuxhumaneni kwe-neuronal liye langanakwa kusukela kumaseli akhazimulayo awenzi ugesi njengama-neurons. Kepha inselele ucwaningo lwe-University of Pittsburg inselele lo mbono futhi usikhanyisa ngendima ebalulekile yama-astrocytes ezempilo nezifo.
Okutholakele kusanda kushicilelwa ngaphakathiUmthombo Wemvelo Wezempilo.
Ucwaningo lwangaphambilini lubonisa ukuthi ukuphazamiseka ezinqubweni zobuchopho ngaphezulu komthwalo we-amyloid, njengokukhuphuka kokuvuvukala kobuchopho, kungahle kudlale indima ebalulekile ekuqaleni kokulandelana kokufa kwe-neuronal okuholela ekunciphiseni kwe-neuronal e-Alzheimer's.
Kulolu cwaningo olusha, abacwaningi beqhuba izivivinyo zegazi kwabahlanganyeli abangu-1 000 abavela ezifundweni ezintathu ezihlukene ezihilela abantu abadala abadala abanempilo futhi ngaphandle kokwakheka kwe-amyloid.
Bahlaziya amasampula egazi ukuze bahlole ama-biomarkers e-astrocyte reartivity, ngokukhethekile amaprotheni e-acibric acidic (GFAP), ngokuhambisana nokuba khona kwe-pathological tau.
Abaphenyi bathola ukuthi yilabo kuphela ababenomthwalo we-amploid kanye namamaki egazi akhombisa ukwenziwa nge-astrocyte astrete noma ukusatshalaliswa kwe-Astrocyte
Isikhathi sePosi: Jun-08-2023